Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | SLC9A3 | P48764 | 7/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15616228 | 1.00 | TSHR (0.46) | TSHRCHRNA7SLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9813886 | 0.98 | CHRNA7 (0.45) | TSHRCHRNA7SLC9A3CYP2D6SLC18A3 | |
| SCHEMBL4918019 | 0.98 | CHRNA7 (0.45) | TSHRCHRNA7SLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9772430 | 0.98 | CHRNA7 (0.45) | TSHRCHRNA7SLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9772303 | 0.85 | SLC18A3 (0.41) | TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL7961950 | 0.85 | SLC18A3 (0.41) | TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9748301 | 0.81 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9498356 | 0.81 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9748308 | 0.81 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9298898 | 0.81 | SLC18A3 (0.37) | CHRNA7SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271395-B1 | E.G.,(.+-.)-N-(2,3-DIHYDRO-2-(1-PYRROLIDINYL)-1H-INDEN-1-Y1) -2 ,4-DINITRO-N-METHYL-BENZENE-ACETAMIDE; STRONG AFFINITY FOR OPTICAL RECEPTORS, CENTRAL ANALGESIC, DIURETIC, ANTIARRYTHMIC, HYPOTENSIVE AND ANTIISCHEMIC ACTIVITY. | HOECHST MARION ROUSSOL (FR) | 2001-08-07 | — | — | US | disclosed |
| US-5234944-A | Analgesic for mammals | ROUSSEL UCLAF (FR) | 1993-08-10 | — | — | US | disclosed |
| EP-0258096-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES OBTAINED | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |
| EP-0258096-A2 | Indane derivatives, process for their preparation, their use as medicines, pharmaceutical compositions containing them and the intermediates obtained | ROUSSEL-UCLAF (FR) | 1988-03-02 | — | — | EP | disclosed |