Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC9A3 | P48764 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813886 | 1.00 | CHRNA7 (0.45) | CHRNA7TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9772430 | 1.00 | CHRNA7 (0.45) | CHRNA7TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL7954485 | 0.98 | TSHR (0.46) | CHRNA7TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL15616228 | 0.98 | TSHR (0.46) | CHRNA7TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9772303 | 0.86 | SLC18A3 (0.41) | TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL7961950 | 0.86 | SLC18A3 (0.41) | TSHRSLC9A3CYP2D6SLC18A3 | |
| SCHEMBL9748301 | 0.83 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9498356 | 0.83 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9748308 | 0.83 | CHRNA7 (0.50) | CHRNA7SLC18A3 | |
| SCHEMBL9298898 | 0.82 | SLC18A3 (0.37) | CHRNA7SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214870-A1 | Method of Preparing Amine Stereoisomers | HAN ZHENGXU | 2008-09-04 | — | — | US | claimed |
| US-7332610-B2 | Method of preparing amine stereoisomers | APSINTERM LLC (US) | 2008-02-19 | — | — | US | claimed |
| EP-1497272-A4 | METHOD OF PREPARING AMINE STEREOISOMERS | APSINTERM LLC (US) | 2007-02-07 | — | — | EP | claimed |
| US-20060287539-A1 | Method of preparing amine stereoisomers | HAN ZHENGXU | 2006-12-21 | — | — | US | claimed |
| US-7129378-B2 | Method of preparing amine stereoisomers | APSINTERM, LLC (US) | 2006-10-31 | — | — | US | claimed |
| US-20050165240-A1 | Method of preparing amine stereoisomers | APSINTERM, LLC | 2005-07-28 | — | — | US | claimed |
| EP-1497272-A2 | METHOD OF PREPARING AMINE STEREOISOMERS | Apsinterm, LLC. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003091207-A2 | METHOD OF PREPARING AMINE STEREOISOMERS | APSINTERM, LLC. (US) | 2003-11-06 | — | — | WO | claimed |
| US-20080214870-A1 | Method of Preparing Amine Stereoisomers | HAN ZHENGXU | 2008-09-04 | — | — | US | disclosed |
| US-7332610-B2 | Method of preparing amine stereoisomers | APSINTERM LLC (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1497272-A4 | METHOD OF PREPARING AMINE STEREOISOMERS | APSINTERM LLC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-20060287539-A1 | Method of preparing amine stereoisomers | HAN ZHENGXU | 2006-12-21 | — | — | US | disclosed |
| US-7129378-B2 | Method of preparing amine stereoisomers | APSINTERM, LLC (US) | 2006-10-31 | — | — | US | disclosed |
| US-20050165240-A1 | Method of preparing amine stereoisomers | APSINTERM, LLC | 2005-07-28 | — | — | US | disclosed |
| US-5010085-A | Analgesis and/or diuretics | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| US-4988727-A | Cardiovascular disorders, analgesics | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4929627-A | ANALGESICS, DIURETICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4888355-A | Indanes and their use as antiarrhythmic agents | ROUSSEL UCLAF (FR) | 1989-12-19 | — | — | US | disclosed |
| US-4876269-A | ANALGESICS, DIURETICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0272982-A2 | Indane derivatives, process for their preparation and intermediates obtained, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165240-A1 | Method of preparing amine stereoisomers | SRM, TST, SMOX | CHRNA7 1766/4885TSHR 1636/4885SLC9A3 3429/4885 |
| US-20080214870-A1 | Method of Preparing Amine Stereoisomers | SRM, PNMT, SMS | CHRNA7 1021/4885TSHR 1850/4885SLC9A3 3356/4885 |
| US-20060287539-A1 | Method of preparing amine stereoisomers | SRM, PNMT, SMS | CHRNA7 1021/4885TSHR 1850/4885SLC9A3 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.