SCHEMBL7961950

SCHEMBL7961950

CN1CCN(C2c3ccccc3CC2O)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 5/20 0.41
SLC9A3 P48764 1/20 0.39
CHRNB2 P17787 1/20 0.38
CHRNA4 P43681 1/20 0.38
DRD2 P14416 3/20 0.38
HRH1 P35367 3/20 0.38
DRD4 P21917 2/20 0.38
HTR2C P28335 2/20 0.38
TP53 P04637 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
TSHR P16473 1/20 0.38
NFKB1 P19838 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38
HIF1A Q16665 1/20 0.38
NPC1 O15118 1/20 0.38
MTOR P42345 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9772303 1.00 SLC18A3 (0.41) SLC18A3SLC9A3CHRNB2CHRNA4DRD2
SCHEMBL9813886 0.86 CHRNA7 (0.45) SLC18A3SLC9A3CYP2D6TSHR
SCHEMBL9772430 0.86 CHRNA7 (0.45) SLC18A3SLC9A3CYP2D6TSHR
SCHEMBL4918019 0.86 CHRNA7 (0.45) SLC18A3SLC9A3CYP2D6TSHR
SCHEMBL15616228 0.85 TSHR (0.46) SLC18A3SLC9A3CYP2D6TSHR
SCHEMBL7954485 0.85 TSHR (0.46) SLC18A3SLC9A3CYP2D6TSHR
SCHEMBL4128316 0.81 SLC18A3 (0.43) SLC18A3
SCHEMBL4128319 0.81 SLC18A3 (0.43) SLC18A3
SCHEMBL9298898 0.79 SLC18A3 (0.37) SLC18A3
SCHEMBL27783391 0.78 MEN1 (0.43) DRD2HRH1HTR2CTP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6271395-B1 E.G.,(.+-.)-N-(2,3-DIHYDRO-2-(1-PYRROLIDINYL)-1H-INDEN-1-Y1) -2 ,4-DINITRO-N-METHYL-BENZENE-ACETAMIDE; STRONG AFFINITY FOR OPTICAL RECEPTORS, CENTRAL ANALGESIC, DIURETIC, ANTIARRYTHMIC, HYPOTENSIVE AND ANTIISCHEMIC ACTIVITY. HOECHST MARION ROUSSOL (FR) 2001-08-07 US disclosed