Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953666 | 0.87 | ELANE (0.58) | ELANE | |
| SCHEMBL7960116 | 0.86 | TSHR (0.45) | ELANEJAK1ALDH1A1JAK2PDE4A | |
| SCHEMBL7966506 | 0.86 | TSHR (0.45) | ELANEJAK1ALDH1A1JAK2PDE4A | |
| SCHEMBL7960265 | 0.83 | ELANE (0.54) | ELANE | |
| SCHEMBL7966421 | 0.83 | ELANE (0.54) | ELANE | |
| SCHEMBL7966469 | 0.83 | ELANE (0.56) | ELANEALDH1A1PDE4AKCNH2 | |
| SCHEMBL7954868 | 0.83 | ELANE (0.56) | ELANEALDH1A1PDE4AKCNH2 | |
| SCHEMBL7966257 | 0.82 | ELANE (0.53) | ELANEALDH1A1 | |
| SCHEMBL7966256 | 0.82 | ELANE (0.53) | ELANEALDH1A1 | |
| SCHEMBL7946372 | 0.82 | ELANE (0.55) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |