Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 19/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.81 |
| ▸ | AR | P10275 | 4/20 | 0.78 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.78 |
| ▸ | ESR1 | P03372 | 2/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955302 | 0.91 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL7953151 | 0.89 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL12899044 | 0.88 | PGR (0.87) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL12886097 | 0.85 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL5358795 | 0.85 | PGR (0.74) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL7955312 | 0.83 | PGR (0.77) | PGRNR3C1AR | |
| SCHEMBL6648084 | 0.83 | PGR (0.78) | PGRNR3C1ARNR3C2 | |
| SCHEMBL5889107 | 0.82 | PGR (0.70) | PGRNR3C1AR | |
| SCHEMBL4179467 | 0.82 | NR3C1 (0.76) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL5889103 | 0.82 | PGR (0.69) | PGRNR3C1ARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268497-B1 | CONVERTING LACTOL PRECURSOR TO ONE OF A SELECT NUMBER OF MIXED ACETAL DERIVATIVES, AND THEN TREATING ACETALS WITH A GRIGNARD REAGENT TO PROVIDE CHROMENOQUINOLINE COMPOUND | LIGAND PHARMACEUTICALS INCORPORATED | 2001-07-31 | — | — | US | disclosed |
| US-6093826-A | Process for the preparation of C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-f] quinolines | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-07-25 | — | — | US | disclosed |