Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957104 | 0.83 | ATM (0.46) | ATMCYP2C9CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL5754955 | 0.79 | COMT (0.44) | ATMTMPRSS4P2RX1P2RX4P2RX7 | |
| SCHEMBL7943951 | 0.78 | TMPRSS4 (0.41) | TMPRSS4P2RX1P2RX4P2RX7CYP2C9 | |
| SCHEMBL5756323 | 0.77 | TMPRSS4 (0.44) | TMPRSS4P2RX1P2RX4P2RX7CYP2C9 | |
| SCHEMBL7950909 | 0.74 | P2RX1 (0.44) | TMPRSS4P2RX1P2RX4P2RX7CYP2C9 | |
| SCHEMBL7953052 | 0.74 | P2RX1 (0.39) | TMPRSS4P2RX1P2RX4P2RX7CYP2C9 | |
| SCHEMBL15551302 | 0.74 | ATM (0.43) | ATMCYP2C9KMT2A | |
| SCHEMBL5754043 | 0.73 | HSD11B1 (0.39) | TMPRSS4KMT2AHDAC6 | |
| SCHEMBL15552791 | 0.73 | ATM (0.42) | ATMCYP2C9KMT2A | |
| SCHEMBL5755561 | 0.72 | MAPT (0.47) | TMPRSS4P2RX1P2RX4P2RX7CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |