Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | MARS1 | P56192 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 3/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953052 | 0.91 | P2RX1 (0.39) | COMTMARS1HSP90AA1MEN1CYP1A2 | |
| SCHEMBL7944372 | 0.90 | HSP90AA1 (0.50) | COMTHSP90AA1MEN1CYP1A2CYP3A4 | |
| SCHEMBL5755561 | 0.88 | MAPT (0.47) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL7944057 | 0.85 | ARF6 (0.37) | COMTMARS1HSP90AA1MEN1CYP1A2 | |
| SCHEMBL7943951 | 0.84 | TMPRSS4 (0.41) | HSP90AA1MEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL7952535 | 0.83 | TNKS (0.43) | MARS1MAPTCYP2C9TSHRKCNMA1 | |
| SCHEMBL5754043 | 0.80 | HSD11B1 (0.39) | HSP90AA1MAPTKMT2ANPSR1PARP1 | |
| SCHEMBL7954586 | 0.79 | ATM (0.48) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5754718 | 0.79 | COMT (0.42) | COMTMARS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7954690 | 0.75 | ALDH1A1 (0.46) | COMTMARS1HSP90AA1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915856-A4 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2006-04-12 | — | — | EP | claimed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | claimed |
| EP-0915856-A1 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 1999-05-19 | — | — | EP | claimed |
| WO-1998004135-A1 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | claimed |
| US-7846671-B2 | Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| US-7846671-B2 | Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| US-20070065883-A1 | Molecules that modulate Galphaq activity and methods of treating urinary incontinence | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-22 | — | — | US | disclosed |
| US-20070065883-A1 | Molecules that modulate Galphaq activity and methods of treating urinary incontinence | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-22 | — | — | US | disclosed |
| EP-0915856-A4 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0915856-A1 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1998004135-A1 | DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | disclosed |