Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.68 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CASP4 | P49662 | 1/20 | 0.60 |
| ▸ | CASP5 | P51878 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127229 | 0.82 | KMT2A (0.66) | MAPTALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6704714 | 0.82 | ALDH1A1 (0.97) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL8111511 | 0.82 | HTT (0.77) | MAPTALDH1A1POLBNPC1HTT | |
| SCHEMBL5626457 | 0.80 | ALDH1A1 (0.74) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL28070725 | 0.80 | HTR1A (0.60) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL22495425 | 0.80 | KMT2A (0.74) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL3151686 | 0.80 | POLB (0.71) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL22418861 | 0.80 | HTT (0.70) | MAPTALDH1A1L3MBTL1POLBNPC1 | |
| SCHEMBL8251966 | 0.80 | MAPT (0.66) | MAPTALDH1A1POLBNPC1HTT | |
| SCHEMBL13219071 | 0.80 | ALDH1A1 (0.74) | MAPTALDH1A1L3MBTL1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |