Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7960144 | 0.99 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| Hydrochloric Acid SCHEMBL7955447 | 0.87 | HTR1A (0.52) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL14578118 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL7954801 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL27487065 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL7946331 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL14578178 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| SCHEMBL7946336 | 0.86 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| Hydrochloric Acid SCHEMBL5180377 | 0.84 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 | |
| Hydrochloric Acid SCHEMBL7953439 | 0.84 | MAOA (0.46) | MAOAMAOBHTR1AHRH3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262078-B1 | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain | SYNTEX (U.S.A.) LLC | 2001-07-17 | — | — | US | disclosed |
| US-6110937-A | A SODIUM CHANNEL BLOCKER TREATING AS LOCAL ANESTHETICS AND IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | SYNTEX USA, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0869119-A1 | Phenoxymethyl piperidine derivatives being sodium channle blockers | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-07 | — | — | EP | disclosed |
| CN-1194977-A | Phenoxymethyl piperidine derivatives | HOFFMANN LA ROCHE (CH) | 1998-10-07 | — | — | CN | disclosed |