Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584765 | 0.84 | NAMPT (0.61) | SLC6A7SMN1; SMN2CYP3A4ALDH1A1GAA | |
| SCHEMBL3640637 | 0.84 | GRM5 (0.63) | SLC6A7SMN1; SMN2AKR1C3CYP3A4ALDH1A1 | |
| SCHEMBL25160524 | 0.83 | NAMPT (0.60) | SLC6A7SMN1; SMN2AKR1C3ALDH1A1NAMPT | |
| SCHEMBL20639683 | 0.83 | GPR183 (0.64) | SLC6A7SMN1; SMN2AKR1C3ALDH1A1NAMPT | |
| SCHEMBL25160076 | 0.83 | GPR183 (0.64) | SLC6A7SMN1; SMN2AKR1C3ALDH1A1NAMPT | |
| SCHEMBL94245 | 0.83 | NAMPT (0.60) | SLC6A7SMN1; SMN2ALDH1A1NAMPTHSD17B10 | |
| SCHEMBL20347007 | 0.83 | LMNA (0.67) | SLC6A7ALDH1A1NAMPTHSD17B10POLB | |
| SCHEMBL7956560 | 0.82 | KDM4E (0.65) | SMN1; SMN2AKR1C3CYP3A4POLB | |
| SCHEMBL15288936 | 0.82 | MKNK1 (0.75) | SLC6A7CYP3A4 | |
| SCHEMBL12082812 | 0.81 | LMNA (0.69) | SLC6A7SMN1; SMN2AKR1C3CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |