Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958537 | 0.92 | MAPT (0.45) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| Hydrochloric Acid SCHEMBL8140883 | 0.91 | MAPT (0.44) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7951743 | 0.84 | MAPT (0.52) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7951760 | 0.83 | MAPT (0.61) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7955615 | 0.81 | HTR1D (0.40) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7953978 | 0.81 | KMT2A (0.53) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7953309 | 0.81 | MAPT (0.42) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7945228 | 0.80 | ABL1 (0.48) | ABL1BCRPDGFRB | |
| SCHEMBL7951767 | 0.80 | MAPT (0.47) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7953316 | 0.80 | PDGFRB (0.47) | MAPTSMN1; SMN2TRPV1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |