Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | BRAF | P15056 | 8/20 | 0.47 |
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953516 | 0.88 | SMN1; SMN2 (0.44) | ABL1EGFRBRAFKITPDGFRB | |
| SCHEMBL7945192 | 0.87 | HTR2A (0.42) | BRAFKIT | |
| SCHEMBL7951869 | 0.86 | EGFR (0.44) | ABL1EGFRBRAFBCR | |
| SCHEMBL7945155 | 0.86 | BRAF (0.51) | BRAFKIT | |
| Hydrochloric Acid SCHEMBL8130753 | 0.86 | HTR2A (0.42) | BRAFKIT | |
| SCHEMBL7958537 | 0.85 | MAPT (0.45) | ABL1PDGFRBBCR | |
| Hydrochloric Acid SCHEMBL8140883 | 0.85 | MAPT (0.44) | ABL1PDGFRBBCR | |
| SCHEMBL7955614 | 0.84 | BRAF (0.44) | BRAF | |
| Hydrochloric Acid SCHEMBL6293727 | 0.84 | KIT (0.53) | ABL1EGFRBRAFKIT | |
| SCHEMBL7953316 | 0.83 | PDGFRB (0.47) | PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |