SCHEMBL7955684

SCHEMBL7955684

COC[C@H]1O[C@@H](Oc2ccc([N+](=O)[O-])cc2)[C@H](OC)[C@@H](O)[C@H]1O

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HPSE Q9Y251 1/20 0.42
CYP1A2 P05177 1/20 0.42
NFKB1 P19838 1/20 0.42
THPO P40225 1/20 0.42
ALDH1A1 P00352 1/20 0.42
PMP22 Q01453 1/20 0.42
MAPT P10636 1/20 0.39
TYR P14679 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7955687 1.00 HPSE (0.42) HPSECYP1A2NFKB1THPOALDH1A1
SCHEMBL8319213 0.94 CYP1A2 (0.39) HPSECYP1A2NFKB1THPOALDH1A1
SCHEMBL7957573 0.94 CYP1A2 (0.39) HPSECYP1A2NFKB1THPOALDH1A1
SCHEMBL7948101 0.89 CYP1A2 (0.53) CYP1A2NFKB1THPOALDH1A1PMP22
SCHEMBL7948106 0.89 CYP1A2 (0.53) CYP1A2NFKB1THPOALDH1A1PMP22
SCHEMBL7962254 0.88 MAPT (0.40) ALDH1A1MAPT
SCHEMBL7962256 0.88 MAPT (0.40) ALDH1A1MAPT
SCHEMBL7957578 0.87 MAPT (0.39) HPSEALDH1A1MAPT
SCHEMBL7955265 0.86 NT5E (0.51) HPSE
SCHEMBL7955271 0.86 NT5E (0.51) HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779888-B1 PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM BOEHRINGER INGELHEIM PHARMA (DE) 1999-04-28 EP claimed
US-5707989-A ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES DR. KARL THOMAE GMBH (DE) 1998-01-13 US claimed
US-6271342-B1 SERUM STABILITY; FOR TUMOR THERAPY BAYER AKTIENGESELLSCHAFT (DE) 2001-08-07 US disclosed
US-5707989-A ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES DR. KARL THOMAE GMBH (DE) 1998-01-13 US disclosed