Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 7/20 | 0.36 |
| ▸ | MMP3 | P08254 | 7/20 | 0.36 |
| ▸ | MMP7 | P09237 | 6/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 6/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | FCER2 | P06734 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955735 | 1.00 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7955737 | 1.00 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7840710 | 0.86 | ADAM17 (0.41) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7840708 | 0.86 | ADAM17 (0.41) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7840713 | 0.86 | ADAM17 (0.41) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7846625 | 0.86 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7960606 | 0.86 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7846628 | 0.86 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7836345 | 0.83 | ADAM17 (0.40) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7836349 | 0.83 | ADAM17 (0.40) | ADAM17APPMMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |