Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 7/20 | 0.36 |
| ▸ | MMP3 | P08254 | 6/20 | 0.36 |
| ▸ | MMP7 | P09237 | 6/20 | 0.36 |
| ▸ | MMP1 | P03956 | 6/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | MMP10 | P09238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957395 | 0.89 | ADAM17 (0.46) | ADAM17APPNPSR1MMP2MMP3 | |
| SCHEMBL7955741 | 0.86 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7955735 | 0.86 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7955737 | 0.86 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7850096 | 0.83 | ADAM17 (0.44) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7850097 | 0.83 | ADAM17 (0.44) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7850095 | 0.83 | ADAM17 (0.44) | ADAM17APPMMP2MMP3MMP7 | |
| SCHEMBL7846628 | 0.83 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7846625 | 0.83 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7960604 | 0.81 | ADAM17 (0.42) | ADAM17APPMMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |