Benzylamine

Benzylamine

SCHEMBL7955985

NCc1ccccc1.O=C1N=c2ccccc2=NC1=O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 4/20 0.58
TAAR1 Q96RJ0 4/20 0.45
CYP2D6 P10635 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
MAOB P27338 1/20 0.40
CYP2A6 P11509 2/20 0.38
HTR2A P28223 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HTR6 P50406 1/20 0.38
PNMT P11086 1/20 0.38
ENPP2 Q13822 1/20 0.38
HRH3 Q9Y5N1 1/20 0.36
ADRB2 P07550 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAOA P21397 2/20 0.34
SLC6A2 P23975 2/20 0.34
SLC6A4 P31645 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21359837 0.77 MAPT (0.38) MAOBSMN1; SMN2MAOA
Hydrochloric Acid SCHEMBL2948518 0.77 MAPT (0.38) MAOBSMN1; SMN2MAOA
Benzylamine SCHEMBL5481672 0.76 LOXL2 (1.00) LOXL2TAAR1CYP2D6CYP1A2CYP2C9
Benzylamine SCHEMBL1331207 0.76
Benzylamine SCHEMBL373 0.76
Benzylamine SCHEMBL10707644 0.76 LOXL2 (1.00) LOXL2TAAR1CYP2D6CYP1A2CYP2C9
SCHEMBL19242392 0.76 LOXL2 (1.00) LOXL2TAAR1CYP2D6CYP1A2CYP2C9
Bicarbonate SCHEMBL9542773 0.75 NPSR1 (0.39) TSHRCYP2C19SMN1; SMN2CYP3A4CA1
Benzylamine SCHEMBL3793054 0.74 LOXL2 (0.82) LOXL2TAAR1CYP2D6CYP1A2CYP2C9
Benzylamine SCHEMBL3793057 0.74 LOXL2 (0.82) LOXL2TAAR1CYP2D6CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6268366-B1 Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists WARNER-LAMBERT COMPANY 2001-07-31 US disclosed
US-6191134-B1 STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS WARNER-LAMBERT COMPANY 2001-02-20 US disclosed
US-6172065-B1 CENTRAL NERVOUS SYSTEM DISORDERS WARNER-LAMBERT COMPANY 2001-01-09 US disclosed
US-6096744-A ANTICONVULSANTS WARNER-LAMBERT COMPANY (US) 2000-08-01 US disclosed
US-6063774-A NERVOUS SYSTEM DISORDERS WARNER-LAMBERT COMPANY (US) 2000-05-16 US disclosed
WO-1998027097-A1 TRICYCLIC QUINOXALINE DERIVATIVES AS NEUROPROTECTIVE AGENTS WARNER-LAMBERT COMPANY (US) 1998-06-25 WO disclosed
WO-1998023599-A1 UREA AND THIOUREA DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-06-04 WO disclosed
WO-1997046539-A1 AMIDE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-12-11 WO disclosed