Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956448 | 0.88 | HTT (0.46) | NAMPTHTR1ADRD2HTTROCK2 | |
| SCHEMBL7947618 | 0.87 | KMT2A (0.49) | NAMPTHTR1ADRD2HTTROCK2 | |
| SCHEMBL7956239 | 0.78 | CYP19A1 (0.46) | NAMPT | |
| SCHEMBL7947622 | 0.77 | MAPT (0.50) | NAMPTHTR1ADRD2HTTROCK2 | |
| SCHEMBL7947475 | 0.75 | KMT2A (0.52) | HTR1ADRD2 | |
| SCHEMBL7967171 | 0.72 | KMT2A (0.54) | HTR1ADRD2 | |
| SCHEMBL7956560 | 0.69 | KDM4E (0.65) | PANK3 | |
| SCHEMBL18695146 | 0.69 | NAMPT (0.64) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL28456273 | 0.69 | NAMPT (0.53) | NAMPT | |
| SCHEMBL20379200 | 0.69 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |