Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967171 | 0.91 | KMT2A (0.54) | KMT2ASCN2ASCN10ADRD2DRD4 | |
| SCHEMBL5334419 | 0.80 | ALDH1A1 (0.51) | KMT2ASCN2ASCN10ADRD2DRD4 | |
| SCHEMBL7947618 | 0.78 | KMT2A (0.49) | KMT2ADRD2HTR1A | |
| Hydrochloric Acid SCHEMBL27908881 | 0.77 | DRD2 (0.72) | DRD2 | |
| SCHEMBL2355678 | 0.76 | DRD3 (0.72) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL7956445 | 0.75 | NAMPT (0.52) | DRD2HTR1A | |
| SCHEMBL7956809 | 0.75 | SETDB1 (0.53) | KMT2ASMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL8635355 | 0.75 | GAA (0.55) | KMT2ASMN1; SMN2DRD2DRD3HTR1A | |
| SCHEMBL5160692 | 0.74 | HTR1A (0.59) | HTR1AADRA1A | |
| SCHEMBL13212055 | 0.73 | POLB (0.62) | KMT2ASCN2ASCN10ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |