Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947618 | 0.88 | KMT2A (0.49) | MAPTHTTHTR1ADRD2NAMPT | |
| SCHEMBL7956448 | 0.85 | HTT (0.46) | HTTHTR1ADRD2NAMPTROCK2 | |
| SCHEMBL7956464 | 0.77 | SMN1; SMN2 (0.47) | MAPTKMT2ASMN1; SMN2MEN1POLB | |
| SCHEMBL7956445 | 0.77 | NAMPT (0.52) | HTTHTR1ADRD2NAMPTROCK2 | |
| SCHEMBL7967171 | 0.74 | KMT2A (0.54) | HTR1ADRD2KMT2A | |
| SCHEMBL7947475 | 0.71 | KMT2A (0.52) | HTR1ADRD2KMT2ASMN1; SMN2 | |
| SCHEMBL26697159 | 0.69 | RAB9A (0.62) | MAPTHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11616834 | 0.68 | HTT (1.00) | HTTNAMPTROCK2ROCK1KMT2A | |
| SCHEMBL7958206 | 0.66 | CCR5 (0.50) | HTTHTR1ASMN1; SMN2POLBF10 | |
| SCHEMBL7956458 | 0.66 | POLB (0.51) | MAPTNAMPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |