Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959643 | 0.87 | NPC1 (0.65) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL9297476 | 0.86 | KMT2A (0.75) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL8110954 | 0.86 | GAA (0.75) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL7956543 | 0.85 | KMT2A (0.66) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL1645837 | 0.84 | GAA (0.73) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL2835288 | 0.84 | GAA (0.73) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL31527868 | 0.84 | GAA (0.73) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL9312776 | 0.84 | GAA (0.84) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL1791238 | 0.84 | GAA (0.73) | GAAKMT2ACYP2C19KDM4EL3MBTL1 | |
| SCHEMBL7955073 | 0.84 | KMT2A (0.60) | GAAKMT2ACYP2C19KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245779-B1 | ANALGESICS; ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-06-12 | — | — | US | disclosed |
| CN-1262685-A | Naphthyridine derivatives | OTSUKA PHARMA CO LTD (JP) | 2000-08-09 | — | — | CN | disclosed |
| EP-0997463-A1 | NAPHTHYRIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-05-03 | — | — | EP | disclosed |