Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15477324 | 0.88 | MAPK1 (0.49) | MAPK1BTKNTRK1MAP3K7IRAK4 | |
| SCHEMBL795592 | 0.84 | CTSL (0.42) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL795967 | 0.83 | NTRK1 (0.43) | MAPK1NTRK1MAP3K7IRAK4NPC1 | |
| SCHEMBL796014 | 0.80 | NPC1 (0.44) | NTRK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL807945 | 0.78 | KMT2A (0.46) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL796061 | 0.78 | GRM5 (0.43) | NTRK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL796307 | 0.78 | KDM4E (0.48) | MAPK1BTKNPC1LMNARAB9A | |
| SCHEMBL795945 | 0.78 | KMT2A (0.47) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL795451 | 0.75 | NAMPT (0.39) | MAPK1NPC1RAB9A | |
| SCHEMBL808334 | 0.75 | MAP4K4 (0.42) | MAPK1NTRK1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |