Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081066 | 0.69 | PARP1 (0.46) | PARP1DAOSMN1; SMN2 | |
| SCHEMBL7954712 | 0.69 | PDE4A (0.48) | MAPTMEN1KMT2AKDM4E | |
| SCHEMBL5872099 | 0.67 | AURKA (0.53) | AURKAPARP1FGFR1FLT1FEN1 | |
| SCHEMBL7954380 | 0.66 | RXFP1 (0.52) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL14224041 | 0.64 | AURKA (0.57) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL6531057 | 0.64 | PARP1 (1.00) | AURKAPARP1MEN1KMT2ADAO | |
| SCHEMBL10528960 | 0.63 | PARP1 (0.70) | AURKAPARP1MAPTMEN1KMT2A | |
| SCHEMBL653371 | 0.62 | AURKA (0.79) | AURKAPARP1MEN1KMT2ADAO | |
| SCHEMBL22185856 | 0.61 | DAO (0.61) | AURKAPARP1DAOKDM4EALDH1A1 | |
| SCHEMBL3358656 | 0.61 | AURKA (0.57) | AURKAPARP1MAPTKMT2ADAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245779-B1 | ANALGESICS; ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0997463-A1 | NAPHTHYRIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-05-03 | — | — | EP | disclosed |