SCHEMBL7956556

SCHEMBL7956556

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ncccc2NC=O)n1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 1/20 0.54
GAA P10253 1/20 0.53
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
GLA P06280 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35
HDAC1 Q13547 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8104436 0.88 GAA (0.56) CDK1GAAMAPTTP53GLA
SCHEMBL8380195 0.86 GAA (0.54) CDK1GAAMAPTTP53GLA
SCHEMBL9522827 0.84 GAA (0.58) CDK1GAAMAPTTP53GLA
SCHEMBL8883721 0.83 GAA (0.57) CDK1GAAMAPTTP53GLA
SCHEMBL11001284 0.83 GAA (0.57) CDK1GAAMAPTTP53GLA
SCHEMBL9020898 0.82 GAA (0.49) CDK1GAAMAPTTP53GLA
SCHEMBL10365723 0.82 GAA (0.56) CDK1GAAMAPTTP53GLA
SCHEMBL9040212 0.82 GAA (0.56) CDK1GAAMAPTTP53GLA
SCHEMBL9628294 0.82 GAA (0.56) CDK1GAAMAPTTP53GLA
SCHEMBL8675183 0.81 GAA (0.55) CDK1GAAMAPTTP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316388-B1 ANTIGROWTH AGENTS FOR PLANTS HOECHST SCHERING AGREVO GMBH (DE) 2001-11-13 US disclosed
US-5847146-A N-heteroartyl-n'-(pyrid-2yl-sulfonyl) ureas, processes for their preparation, and their use as herbicides and plant growth regulators HOECHST SCHERING AGREVO GMBH (DE) 1998-12-08 US disclosed
EP-0555770-A1 N-Heteroaryl-N'-(pyrid-2-yl-sulfonyl)-ureas, process for their preparation, and their use as herbicides and plant growth regulators Hoechst Schering AgrEvo GmbH (DE) 1993-08-18 EP disclosed