Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | ILK | Q13418 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | NCS1 | P62166 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512218 | 0.80 | DYRK1A (0.47) | DYRK1AILKPOLBKDM4EMEN1 | |
| SCHEMBL8133603 | 0.77 | DYRK1A (0.41) | DYRK1AILKEPHX2SCN4AALOX5 | |
| SCHEMBL4238354 | 0.76 | SMN1; SMN2 (0.53) | ALOX5MEN1KMT2ALMNAMAPT | |
| SCHEMBL21048412 | 0.76 | DYRK1A (0.45) | DYRK1AILKALOX5NCS1AKR1B1 | |
| SCHEMBL9853857 | 0.76 | POLB (0.56) | DYRK1AILKEPHX2SCN4AALOX5 | |
| SCHEMBL3660267 | 0.75 | MPL (0.33) | — | |
| SCHEMBL19828320 | 0.74 | DYRK1A (0.41) | DYRK1AILKALOX5NCS1AKR1B1 | |
| SCHEMBL19828322 | 0.74 | ILK (0.39) | DYRK1AILKEPHX2SCN4AALOX5 | |
| SCHEMBL34472341 | 0.74 | DYRK1A (0.46) | DYRK1AILKEPHX2SCN4AALOX5 | |
| SCHEMBL15708155 | 0.74 | DYRK1A (0.54) | DYRK1AILKEPHX2SCN4AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |