Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 14/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 14/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955141 | 1.00 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL7944684 | 0.91 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7957953 | 0.90 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL6782946 | 0.85 | ADRA1D (0.63) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8318805 | 0.84 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL7978685 | 0.81 | ADRA1A (0.53) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6201662 | 0.78 | ADRA1D (0.61) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6785268 | 0.77 | ADRA1D (0.60) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7993242 | 0.77 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7958003 | 0.77 | ADRA1A (0.47) | ADRA1DADRA1AADRA1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228861-B1 | BENIGN PROSTATIC HYPERPLASIA; ANTICHOLESTEROL AGENTS; IMPOTENCY; INTRAOCULAR PRESSURE; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-05-08 | — | — | US | disclosed |
| US-6172066-B1 | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-01-09 | — | — | US | disclosed |