Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 11/20 | 0.49 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7957768 | 1.00 | DRD3 (0.49) | DRD3DRD2KDM4EALDH1A1MAPT | |
| Oxalic Acid SCHEMBL7097823 | 0.94 | DRD3 (0.51) | DRD3DRD2ALDH1A1CACNA2D1CACNA1B | |
| SCHEMBL7098300 | 0.94 | DRD2 (0.49) | DRD3DRD2ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL7098258 | 0.93 | DRD2 (0.49) | DRD3DRD2ALDH1A1MAPTHTT | |
| Bromide SCHEMBL7100449 | 0.93 | DRD2 (0.49) | DRD3DRD2ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL7101513 | 0.93 | DRD2 (0.49) | DRD3DRD2ALDH1A1MAPTHTT | |
| SCHEMBL7098340 | 0.91 | DRD2 (0.45) | DRD3DRD2CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL7097625 | 0.86 | DRD3 (0.57) | DRD3DRD2HRH1SLC6A2HRH2 | |
| SCHEMBL7099285 | 0.86 | DRD3 (0.57) | DRD3DRD2HRH1SLC6A2HRH2 | |
| SCHEMBL7103672 | 0.86 | DRD3 (0.57) | DRD3DRD2HRH1SLC6A2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |