Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 15/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133106 | 0.80 | CYP11B1 (0.63) | CYP11B1CYP11B2IDO1SMN1; SMN2CYP19A1 | |
| SCHEMBL5935193 | 0.80 | CYP11B1 (0.63) | CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL7986619 | 0.80 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL7983220 | 0.79 | CYP11B1 (0.62) | CYP11B1CYP11B2IDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1758083 | 0.78 | CYP11B1 (0.68) | CYP11B1CYP11B2IDO1ALDH1A1LMNA | |
| SCHEMBL8136362 | 0.77 | CYP11B1 (0.56) | CYP11B1CYP11B2IDO1 | |
| SCHEMBL8140959 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1CYP19A1 | |
| SCHEMBL7700254 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1CYP19A1 | |
| SCHEMBL765399 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7696780 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009125-A1 | NOVEL 8-CARBONYL CHROMAN DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |
| WO-2001009127-A1 | BENZOXAZINE DERIVATIVES AND THEIR THERAPEUTIC USE | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |
| WO-2001009124-A1 | 8-CARBONYL CHROMAN DERIVATIVES, PREPARATION AND THERAPIC USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |
| EP-1054882-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041248-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 1999-08-19 | — | — | WO | disclosed |