SCHEMBL8136362

SCHEMBL8136362

O=Cc1cncn1Cc1ccc(-c2ccsc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 9/20 0.56
CYP11B2 P19099 9/20 0.56
CYP17A1 P05093 3/20 0.48
ERN1 O75460 1/20 0.40
CYP2A6 P11509 2/20 0.37
CHEK2 O96017 1/20 0.36
IDO1 P14902 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2B6 P20813 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5935193 0.82 CYP11B1 (0.63) CYP11B1CYP11B2CYP17A1IDO1
SCHEMBL8133106 0.82 CYP11B1 (0.63) CYP11B1CYP11B2CYP2A6IDO1CYP2B6
SCHEMBL7983220 0.81 CYP11B1 (0.62) CYP11B1CYP11B2IDO1
SCHEMBL8150460 0.80 CYP11B1 (0.48) CYP11B1CYP11B2CYP17A1CYP2A6IDO1
SCHEMBL8150463 0.80 CYP11B1 (0.54) CYP11B1CYP11B2CYP17A1CYP2A6IDO1
SCHEMBL14476244 0.77 CYP11B1 (0.58) CYP11B1CYP11B2IDO1
SCHEMBL8131698 0.77 CYP11B1 (0.58) CYP11B1CYP11B2CYP2A6IDO1
SCHEMBL7958104 0.77 CYP11B1 (0.58) CYP11B1CYP11B2IDO1
SCHEMBL7973153 0.77 CYP11B1 (0.58) CYP11B1CYP11B2ERN1CYP2A6IDO1
SCHEMBL1758083 0.77 CYP11B1 (0.68) CYP11B1CYP11B2CYP2A6IDO1CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054882-A1 CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Aventis Pharma S.A. (FR) 2000-11-29 EP disclosed
WO-1999041248-A1 CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AVENTIS PHARMA S.A. (FR) 1999-08-19 WO disclosed