Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14115711 | 0.85 | PDE4B (0.52) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL7009102 | 0.85 | PDE4B (0.49) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL582299 | 0.84 | NR3C1 (0.61) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL8285844 | 0.84 | PDE4B (0.48) | PDE4B | |
| Hydrochloric Acid SCHEMBL7008243 | 0.82 | NR3C1 (0.60) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL9836656 | 0.81 | PDE4B (0.53) | PDE4BPDE5ANR3C1MEN1MAPT | |
| Hydrochloric Acid SCHEMBL11746149 | 0.80 | PDE4B (0.52) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL7971243 | 0.80 | PDE4B (0.46) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL11396345 | 0.80 | PDE5A (0.54) | PDE4BPDE5ANR3C1MEN1MAPT | |
| SCHEMBL11602092 | 0.78 | PDE4B (0.56) | PDE4BPDE5ANR3C1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316438-B1 | Fused pyridopyridazine inhibitors of cGMP phosphodiesterase | BRISTOL-MYERS SQUIBB CO. | 2001-11-13 | — | — | US | disclosed |