Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11746149 | 0.99 | PDE4B (0.52) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL11746143 | 0.88 | PDE4B (0.51) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL11531729 | 0.88 | PDE4B (0.53) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL2772405 | 0.86 | PDE4B (0.65) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL14115711 | 0.81 | PDE4B (0.52) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL7009102 | 0.81 | PDE4B (0.49) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL7958253 | 0.81 | PDE4B (0.49) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL582299 | 0.80 | NR3C1 (0.61) | PDE4BPDE5AMEN1MAPTHPGD | |
| SCHEMBL8285844 | 0.80 | PDE4B (0.48) | PDE4B | |
| Hydrochloric Acid SCHEMBL7008243 | 0.79 | NR3C1 (0.60) | PDE4BPDE5AMEN1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180318-B1 | AMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4745121-A | AMINE OR CARBOXAMIDE SUBSTITUTED | ICI AMERICAS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0180318-A1 | Amide derivatives | ICI AMERICAS INC. (US) | 1986-05-07 | — | — | EP | disclosed |
| US-4012373-A | ANTIINFLAMMATORY, CNS DEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-03-15 | — | — | US | disclosed |