Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.63 |
| ▸ | TP53 | P04637 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.60 |
| ▸ | RELA | Q04206 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063496 | 0.93 | NR1H4 (0.67) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL12643444 | 0.91 | NR1H4 (0.53) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL13525778 | 0.89 | NPC1 (0.70) | SMN1; SMN2TP53MEN1KMT2AHSD17B10 | |
| SCHEMBL20968282 | 0.89 | NPC1 (0.60) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL12586868 | 0.88 | HSD17B1 (0.55) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL13415309 | 0.87 | NR1H4 (0.80) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL8039918 | 0.83 | CHRNB2 (0.71) | SMN1; SMN2TP53HSD17B10KDM4EALDH1A1 | |
| SCHEMBL2062609 | 0.82 | NR1H4 (0.78) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL3061782 | 0.82 | NR1H4 (0.78) | NR1H4SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL8051903 | 0.82 | SMN1; SMN2 (0.66) | NR1H4SMN1; SMN2TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |