Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.66 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | CHKA | P35790 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561698 | 0.88 | TRIM24 (0.83) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3077544 | 0.88 | TRIM24 (0.83) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23922755 | 0.84 | POLB (0.63) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28699791 | 0.84 | SMN1; SMN2 (0.69) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28704014 | 0.81 | TRIM24 (0.56) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28112415 | 0.81 | CHKA (0.80) | SMN1; SMN2KDM4ECHKAADRB2NCF1 | |
| SCHEMBL7660354 | 0.80 | MAPT (0.62) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1443539 | 0.80 | TRIM24 (0.70) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL253732 | 0.79 | TRIM24 (1.00) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7180854 | 0.79 | TRIM24 (0.91) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |