Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP4 | P49662 | 1/20 | 0.47 |
| ▸ | CASP5 | P51878 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392263 | 0.85 | DRD4 (0.70) | TRIM24TRIM33ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7958672 | 0.84 | TRIM24 (0.66) | TRIM24TRIM33ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28710553 | 0.83 | HDAC3 (0.57) | POLBALDH1A1KDM4ESMN1; SMN2DRD4 | |
| SCHEMBL27371894 | 0.81 | DRD4 (0.71) | POLBALDH1A1KDM4EDRD4DRD2 | |
| SCHEMBL1509470 | 0.80 | POLB (0.63) | POLBALDH1A1KDM4ESMN1; SMN2DRD4 | |
| SCHEMBL1669246 | 0.80 | DRD4 (0.77) | POLBALDH1A1KDM4EDRD4DRD2 | |
| SCHEMBL27990811 | 0.79 | HRH3 (0.52) | POLBTRIM24TRIM33ALDH1A1KDM4E | |
| SCHEMBL4579770 | 0.78 | POLB (0.61) | POLBALDH1A1KDM4ESMN1; SMN2DRD4 | |
| SCHEMBL28710385 | 0.78 | ALDH1A1 (0.47) | POLBTRIM24TRIM33ALDH1A1KDM4E | |
| SCHEMBL27373181 | 0.78 | POLB (0.60) | POLBALDH1A1KDM4EDRD4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |