Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957860 | 0.90 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1MAPTKDM4E | |
| SCHEMBL1820450 | 0.88 | AKR1B1 (0.38) | AKR1B1AKR1B10AKR1A1MAPTKDM4E | |
| SCHEMBL7957182 | 0.85 | ALOX12 (0.39) | AKR1B1AKR1B10AKR1A1MAPTKDM4E | |
| SCHEMBL1824045 | 0.81 | AKR1B1 (0.37) | AKR1B1AKR1B10AKR1A1MAPTKDM4E | |
| SCHEMBL1823883 | 0.77 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1MAPTKDM4E | |
| SCHEMBL7971361 | 0.77 | LMNA (0.39) | MAPTKDM4EALDH1A1LMNAALOX12 | |
| SCHEMBL7956191 | 0.74 | AKR1B1 (0.47) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL1826356 | 0.72 | MAOB (0.44) | AKR1B1AKR1B10AKR1A1ALDH1A1GAA | |
| SCHEMBL1821671 | 0.72 | ALOX12 (0.39) | AKR1B1AKR1B10AKR1A1KDM4EHSD17B10 | |
| SCHEMBL7957786 | 0.72 | AKR1B1 (0.55) | AKR1B1AKR1B10AKR1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |