Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385135 | 0.90 | HDAC6 (0.74) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL18811751 | 0.87 | HDAC1 (0.56) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL22106236 | 0.87 | HDAC1 (0.56) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL16810264 | 0.86 | HDAC6 (0.60) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL19928652 | 0.82 | POLB (0.62) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL7958723 | 0.82 | DRD2 (0.55) | HDAC6HDAC1HDAC4HDAC8KMT2A | |
| SCHEMBL28818566 | 0.81 | ALDH1A1 (0.61) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL3013154 | 0.81 | ALDH1A1 (0.61) | HDAC6HDAC1HDAC4KCNH2RAB9A | |
| SCHEMBL2776747 | 0.80 | ALDH1A1 (0.59) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| Hydrochloric Acid SCHEMBL28833528 | 0.80 | ALDH1A1 (0.59) | HDAC6HDAC1HDAC4KCNH2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089479-A1 | METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-06-18 | — | — | WO | disclosed |