Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948724 | 0.82 | MCL1 (0.55) | HTR6 | |
| SCHEMBL7960415 | 0.82 | HTR2C (0.51) | HTR2CSIGMAR1DUT | |
| SCHEMBL12543673 | 0.81 | HTR2C (0.60) | HTR2CPRMT5HTR6 | |
| SCHEMBL7959260 | 0.81 | HTR2C (0.54) | HTR2CPRMT5HTR6SIGMAR1P2RX7 | |
| SCHEMBL7958454 | 0.75 | HTR2C (0.60) | HTR2CPRMT5HTR6 | |
| SCHEMBL6775018 | 0.74 | HTR6 (0.61) | HTR2CPRMT5HTR6P2RX7 | |
| SCHEMBL12542708 | 0.74 | HTR2C (0.58) | HTR2CPRMT5HTR6 | |
| SCHEMBL13228252 | 0.73 | HTR2C (0.65) | HTR2CPRMT5HTR6 | |
| SCHEMBL23927902 | 0.72 | HTR2C (0.64) | HTR2CPRMT5HTR6 | |
| Ethane SCHEMBL7937068 | 0.72 | HTR6 (0.60) | HTR2CPRMT5HTR6P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |