Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206484 | 1.00 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CS1PR1 | |
| SCHEMBL7206486 | 1.00 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CS1PR1 | |
| SCHEMBL7400096 | 0.90 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL5057946 | 0.90 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7205164 | 0.90 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL5056368 | 0.90 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7960396 | 0.89 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CS1PR1 | |
| SCHEMBL2882721 | 0.86 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL13350269 | 0.86 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CS1PR1 | |
| SCHEMBL2882717 | 0.86 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-6191138-B1 | THERAPY FOR RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-20 | — | — | US | disclosed |