Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955219 | 0.84 | PDE5A (0.66) | PDE5ANR3C1PDE4BPDE4D | |
| SCHEMBL7947698 | 0.80 | PDE5A (0.60) | PDE5ANR3C1PDE4BSMN1; SMN2 | |
| SCHEMBL7955535 | 0.80 | PDE5A (0.72) | PDE5ANR3C1PDE4B | |
| SCHEMBL7955235 | 0.80 | PDE5A (0.75) | PDE5AKDM4EPDE4BSMN1; SMN2 | |
| SCHEMBL7947832 | 0.76 | PDE5A (0.60) | PDE5ANR3C1PDE4B | |
| SCHEMBL4338651 | 0.76 | NR3C1 (0.82) | PDE5ANR3C1PDE4B | |
| SCHEMBL4339585 | 0.76 | PDE4B (0.72) | PDE5ANR3C1PDE4BPDE4D | |
| SCHEMBL7955231 | 0.75 | PDE4B (0.48) | KDM4EPDE4BPDE4D | |
| SCHEMBL7955233 | 0.75 | PDE4B (0.48) | KDM4EPDE4BPDE4D | |
| SCHEMBL7948031 | 0.75 | PDE5A (0.82) | PDE5ANR3C1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |