Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947692 | 0.83 | PDE4B (0.59) | PDE5APDE4BNR3C1 | |
| SCHEMBL4348757 | 0.82 | PDE4B (0.85) | PDE5APDE4BNR3C1 | |
| SCHEMBL7955219 | 0.81 | PDE5A (0.66) | PDE5APDE4BNR3C1 | |
| SCHEMBL7958848 | 0.80 | PDE5A (0.58) | PDE5APDE4BNR3C1SMN1; SMN2 | |
| SCHEMBL7955535 | 0.80 | PDE5A (0.72) | PDE5APDE4BNR3C1 | |
| SCHEMBL7957461 | 0.78 | PDE5A (0.74) | PDE5APDE4B | |
| SCHEMBL5962686 | 0.78 | PDE4B (0.80) | PDE5APDE4BNR3C1 | |
| SCHEMBL4339585 | 0.77 | PDE4B (0.72) | PDE5APDE4BNR3C1 | |
| SCHEMBL7948031 | 0.77 | PDE5A (0.82) | PDE5APDE4BNR3C1 | |
| SCHEMBL4335267 | 0.77 | PDE4B (0.71) | PDE5APDE4BNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |