Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 5/20 | 0.63 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.61 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953343 | 0.86 | CTSD (0.59) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL10953336 | 0.86 | CTSD (0.59) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL4943873 | 0.86 | CYSLTR1 (0.58) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL7968159 | 0.86 | CTSD (0.65) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL481227 | 0.85 | CYSLTR1 (0.64) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL10728099 | 0.85 | CYSLTR1 (0.64) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL2894682 | 0.85 | CYSLTR1 (0.64) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL7971466 | 0.85 | CTSD (0.65) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL9120538 | 0.85 | MAPT (0.67) | CTSDCYSLTR1CYSLTR2GRM2PPARG | |
| SCHEMBL10952448 | 0.85 | CTSD (0.58) | CTSDCYSLTR1CYSLTR2GRM2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |