Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 6/20 | 0.65 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971466 | 0.90 | CTSD (0.65) | CTSDPDCD1CD274CYSLTR1CYSLTR2 | |
| SCHEMBL7958997 | 0.86 | CTSD (0.63) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL7971603 | 0.80 | CTSD (0.65) | CTSDCYSLTR1CYSLTR2 | |
| SCHEMBL7971652 | 0.79 | CTSD (1.00) | CTSD | |
| SCHEMBL7971649 | 0.79 | CTSD (1.00) | CTSD | |
| SCHEMBL6936538 | 0.77 | PTGER1 (0.50) | CTSD | |
| SCHEMBL10952453 | 0.76 | CTSD (0.58) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL10952448 | 0.76 | CTSD (0.58) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL10953336 | 0.76 | CTSD (0.59) | CTSDCYSLTR1CYSLTR2GRM2 | |
| SCHEMBL10953343 | 0.76 | CTSD (0.59) | CTSDCYSLTR1CYSLTR2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |