Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 1/20 | 0.54 |
| ▸ | F11 | P03951 | 1/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 14/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976836 | 0.90 | F10 (0.54) | F9F10F11F7CHEK2 | |
| SCHEMBL20307774 | 0.88 | F10 (0.67) | F9F10F11F7CHEK2 | |
| SCHEMBL20307818 | 0.83 | SIRT2 (0.46) | F9F10F11F7CHEK2 | |
| SCHEMBL7959397 | 0.81 | CHEK2 (0.68) | F9F10F11F7CHEK2 | |
| SCHEMBL7978282 | 0.79 | CHEK2 (0.56) | F9F10F11F7CHEK2 | |
| SCHEMBL7972721 | 0.78 | CHEK2 (0.67) | F9F10F11F7CHEK2 | |
| SCHEMBL7960699 | 0.77 | F10 (0.67) | F9F10F11F7CHEK2 | |
| SCHEMBL7969187 | 0.77 | F10 (0.67) | F9F10F11F7 | |
| SCHEMBL17393379 | 0.77 | CHEK2 (0.56) | CHEK2MEN1KMT2ATHRBKDM4E | |
| SCHEMBL17393611 | 0.77 | CHEK2 (0.56) | CHEK2MEN1KMT2ATHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |