Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731336 | 0.82 | NPC1 (0.50) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL679561 | 0.78 | NPC1 (0.47) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL27546185 | 0.74 | ALDH1A1 (0.40) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL29489303 | 0.73 | FYN (0.42) | RAB9AALDH1A1MAPTHPGDMAOB | |
| SCHEMBL8902488 | 0.73 | BACE1 (0.46) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL8007243 | 0.72 | NPC1 (0.93) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL11180936 | 0.72 | NPC1 (0.46) | NPC1RAB9AALDH1A1LMNAHPGD | |
| Biphenyl SCHEMBL15657385 | 0.71 | ALDH1A1 (0.60) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL28199530 | 0.70 | CFTR (0.40) | NPC1RAB9ACFTRGOPCALDH1A1 | |
| SCHEMBL602159 | 0.70 | GSK3A (0.41) | ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114426510-A | Synthesis method of fully-substituted beta-lactam | 常州大学 | 2022-05-03 | — | — | CN | disclosed |
| WO-2012073038-A2 | COMPOUNDS AND METHODS OF MAKING THE SAME | UNIVERSITY OF SHEFFIELD (GB) | 2012-06-07 | — | — | WO | disclosed |
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0559743-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. | PFIZER HOSPITAL PROD (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009566-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER INC. (US) | 1992-06-11 | — | — | WO | disclosed |