Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 11/20 | 0.58 |
| ▸ | DRD2 | P14416 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | SOD1 | P00441 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949588 | 0.90 | SLC6A4 (0.49) | CACNA1GKDM4EGAADRD4DRD2 | |
| SCHEMBL10759040 | 0.88 | DRD4 (0.47) | CACNA1GKDM4EGAADRD4DRD2 | |
| SCHEMBL7957399 | 0.87 | DRD2 (0.58) | CACNA1GGAADRD4DRD2HTR1A | |
| SCHEMBL2388474 | 0.87 | GFER (0.52) | CACNA1GKDM4EGAADRD4DRD2 | |
| SCHEMBL8160104 | 0.87 | HTR1A (0.58) | CACNA1GDRD4DRD2HTR1AHTR2A | |
| SCHEMBL10759929 | 0.86 | KCNH2 (0.64) | CACNA1GDRD4DRD2HTR1AHTR2A | |
| SCHEMBL460673 | 0.85 | HRH3 (0.50) | CACNA1GKDM4EGAADRD4DRD2 | |
| SCHEMBL381687 | 0.84 | DRD2 (0.57) | DRD4DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL20271984 | 0.84 | SMN1; SMN2 (0.69) | KDM4EGAADRD4DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8838070 | 0.84 | HRH3 (0.56) | DRD4HTR2AHTR2CHRH1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |