⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153904 | 0.76 | — | — | |
| SCHEMBL27276410 | 0.74 | MEN1 (0.35) | — | |
| SCHEMBL9487040 | 0.73 | — | — | |
| SCHEMBL1820046 | 0.73 | — | — | |
| SCHEMBL7469857 | 0.73 | — | — | |
| SCHEMBL4259769 | 0.71 | PRKCZ (0.56) | — | |
| SCHEMBL10713072 | 0.68 | PRKCZ (0.40) | — | |
| SCHEMBL15743258 | 0.68 | PRKCZ (0.40) | — | |
| SCHEMBL8850228 | 0.68 | PRKCZ (0.58) | — | |
| SCHEMBL7463317 | 0.68 | GLA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59042376-A | — | — | None | — | — | JP | disclosed |
| US-6303613-B1 | AS NITRIC OXIDE SYNTHASE INHIBITOR USEFUL IN THERAPY OR PROPHYLAXIS OF INFLAMMATORY DISEASE AND PAIN | ASTRAZENECA AB (SE) | 2001-10-16 | — | — | US | disclosed |
| CN-1259131-A | Compound (I) | ASTRA PHARMA PROD (GB) | 2000-07-05 | — | — | CN | disclosed |
| EP-0973772-A1 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045294-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-15 | — | — | WO | disclosed |
| US-5206375-A | Thiophene derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1993-04-27 | — | — | US | disclosed |
| EP-0251120-B1 | DISAZOTHIOPHENE DYES | BASF Aktiengesellschaft (DE) | 1990-08-29 | — | — | EP | disclosed |
| EP-0193885-B1 | THIOPHENE DERIVATIVES | BASF Aktiengesellschaft (DE) | 1989-06-14 | — | — | EP | disclosed |
| US-4837269-A | FIBER-REACTIVE DISAZO DYES | BASF AKTIENGESELLSCHAFT (DE) | 1989-06-06 | — | — | US | disclosed |
| EP-0251120-A2 | Disazothiophene dyes | BASF Aktiengesellschaft (DE) | 1988-01-07 | — | — | EP | disclosed |
| JP-S5942376-A | THIOPHENE COMPOUND AND ITS PREPARATION | NIPPON KAYAKU CO LTD | 1984-03-08 | — | — | JP | disclosed |