Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517058 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1HTTKMT2ARAB9A | |
| SCHEMBL7516271 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1HTTKMT2ARAB9A | |
| SCHEMBL7973282 | 0.77 | MEN1 (0.33) | SMN1; SMN2MEN1HTTKMT2ARAB9A | |
| SCHEMBL7525016 | 0.69 | KMT2A (0.38) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7524432 | 0.68 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1HTTKMT2ARAB9A | |
| SCHEMBL11730797 | 0.67 | CNR2 (0.32) | EPHX2 | |
| SCHEMBL7519607 | 0.66 | FFAR2 (0.34) | — | |
| SCHEMBL7519247 | 0.65 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1HTTKMT2ARAB9A | |
| SCHEMBL7526790 | 0.65 | ALDH1A1 (0.40) | SMN1; SMN2HTTKMT2ARAB9ANPC1 | |
| SCHEMBL11731624 | 0.65 | KDM4E (0.32) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333346-B1 | AMINOFURANONEUREAS OR THIOUREAS 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | ROCHE DIAGNOSTICS GMBH (DE) | 2001-12-25 | — | — | US | disclosed |
| EP-1009747-A1 | UREIDO AND THIOUREIDO DERIVATIVES OF 4-AMINO-2(5H)-FURANONES AND 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999012917-A1 | UREIDO AND THIOUREIDO DERIVATIVES OF 4-AMINO-2(5H)-FURANONES AND 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-18 | — | — | WO | disclosed |