Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953633 | 0.89 | PLAU (0.41) | PLAUKMT2ACYP3A4ABCC1CLK2 | |
| SCHEMBL7954939 | 0.87 | PLAU (0.38) | PLAUKMT2ACYP3A4ABCC1CLK2 | |
| SCHEMBL7946455 | 0.87 | HPGD (0.38) | KMT2ACYP3A4ABCC1CSNK1DCSNK1E | |
| SCHEMBL7946555 | 0.87 | PLAU (0.38) | PLAUKMT2ACYP3A4ABCC1CLK2 | |
| SCHEMBL7946444 | 0.78 | ALDH1A1 (0.43) | ABCC1KDM4EALDH1A1 | |
| SCHEMBL7957120 | 0.78 | HPGD (0.38) | PLAUKMT2ACYP3A4ABCC1KCNK3 | |
| SCHEMBL7957167 | 0.77 | MKNK1 (0.40) | KMT2ACSNK1DCSNK1EMEN1MKNK1 | |
| SCHEMBL7957179 | 0.76 | KMT2A (0.40) | KMT2ACYP3A4ABCC1CSNK1DCSNK1E | |
| SCHEMBL7955823 | 0.76 | MKNK1 (0.41) | KMT2ACYP3A4ABCC1KCNK3CSNK1D | |
| SCHEMBL7946519 | 0.75 | PLAU (0.41) | PLAUCYP3A4ABCC1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |