Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967472 | 0.90 | CYP11B2 (0.39) | CYP11B2CYP11B1PARP1CSNK1A1CSNK1D | |
| SCHEMBL7962248 | 0.88 | CYP11B2 (0.31) | CYP11B2 | |
| SCHEMBL7961423 | 0.86 | CYP11B2 (0.37) | CYP11B2CYP11B1PARP1CSNK1A1CSNK1D | |
| SCHEMBL7953220 | 0.84 | CYP11B2 (0.36) | CYP11B2CYP11B1PARP1 | |
| SCHEMBL7964496 | 0.84 | CYP11B2 (0.35) | CYP11B2CYP11B1PARP1 | |
| SCHEMBL7946704 | 0.82 | CYP11B2 (0.39) | CYP11B2CYP11B1CSNK1A1CSNK1DGSK3B | |
| SCHEMBL8327467 | 0.81 | DHODH (0.36) | CYP11B2CYP11B1PARP1 | |
| SCHEMBL7964888 | 0.80 | CYP11B2 (0.32) | CYP11B2 | |
| SCHEMBL7952345 | 0.80 | CYP11B2 (0.34) | CYP11B2CYP11B1PARP1 | |
| SCHEMBL7963714 | 0.80 | CYP11B2 (0.34) | CYP11B2CYP11B1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |