SCHEMBL7960686

SCHEMBL7960686

O=CCN(C(=O)OCc1ccccc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
MAPT P10636 1/20 0.47
HPGD P15428 1/20 0.47
CHRM2 P08172 1/20 0.46
CHRM5 P08912 1/20 0.46
CHRM1 P11229 1/20 0.46
CHRM3 P20309 1/20 0.46
HCAR2 Q8TDS4 1/20 0.45
TDP1 Q9NUW8 2/20 0.45
PAX8 Q06710 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
MAPK1 P28482 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A3 Q01959 1/20 0.45
KMT2A Q03164 1/20 0.45
CCR6 P51684 1/20 0.45
SIGMAR1 Q99720 1/20 0.43
LMNA P02545 2/20 0.43
ENPP2 Q13822 1/20 0.41
NPC1 O15118 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8241261 0.88 TSHR (0.50) ALDH1A1MAPTHPGDCHRM5CHRM1
SCHEMBL3081849 0.86 HCAR2 (0.47) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL8684866 0.83 SMN1; SMN2 (0.51) ALDH1A1MAPTHPGDL3MBTL1KMT2A
SCHEMBL70301 0.82 CCR6 (0.55) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL28459939 0.81 ALDH1A1 (0.58) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL10377193 0.81 ALDH1A1 (0.49) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL84134 0.81 ALDH1A1 (0.49) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL9359355 0.81 ALDH1A1 (0.53) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL9680281 0.80 ALDH1A1 (0.55) ALDH1A1MAPTHPGDCHRM2CHRM5
SCHEMBL11790891 0.79 ALDH1A1 (0.48) ALDH1A1MAPTHPGDCHRM2CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6271238-B1 USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2001-08-07 US disclosed
EP-0936216-A1 NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1999-08-18 EP disclosed