Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773755 | 0.98 | NPY5R (0.54) | NPY5RKDM4EALDH1A1MEN1GLA | |
| SCHEMBL5775242 | 0.93 | NPY5R (0.49) | NPY5RKDM4EALDH1A1MEN1GLA | |
| SCHEMBL8126501 | 0.88 | NPY5R (0.46) | NPY5RKDM4EALDH1A1KITHPGD | |
| SCHEMBL7963644 | 0.87 | KDM4E (0.46) | NPY5RKDM4EALDH1A1MEN1GLA | |
| SCHEMBL5771896 | 0.87 | NPY5R (0.52) | NPY5RKDM4EKMT2AL3MBTL1HSD17B10 | |
| SCHEMBL5773349 | 0.87 | NPY5R (0.52) | NPY5RKDM4EKMT2AL3MBTL1HSD17B10 | |
| SCHEMBL5771652 | 0.86 | MAPK8 (0.47) | NPY5RKITHPGD | |
| SCHEMBL5773681 | 0.85 | NPY5R (0.54) | NPY5RKDM4EKMT2AL3MBTL1HPGD | |
| Hydrochloric Acid SCHEMBL5798034 | 0.85 | KDM4E (0.45) | NPY5RKDM4EALDH1A1MEN1GLA | |
| SCHEMBL5772625 | 0.84 | MELK (0.45) | NPY5RKDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |